High Cooperativity in Negative Feedback can Amplify Noisy Gene Expression
نویسندگان
چکیده
منابع مشابه
Arm-domain interactions can provide high binding cooperativity.
Peptidyl arms extending from one protein domain to another protein domain mediate many important interactions in biology. A well-studied example of this type of protein-protein interaction occurs between the yeast homeodomain proteins, MAT alpha2 and MAT a1, which form a high-affinity heterodimer on DNA. The carboxyl-terminal arm extending from MAT alpha2 to MAT a1 has been proposed to produce ...
متن کاملStructural basis of negative cooperativity in transthyretin.
A comparison of the AC and BD binding sites of transthyretin (TTR) was made in terms of the interatomic distances between the Ca atoms of equivalent amino acids, measured across the tetramer channel in each binding site. The comparison of the channel diameter for apo TTR from different sources revealed that in the unliganded transthyretin tetramers the distances between the A, D and H beta-stra...
متن کاملGene Expression Changes in Pomegranate Peel Extract-Treated Triple-Negative Breast Cancer Cells
Background: Triple-negative breast cancer (TNBC) is treated with highly aggressive non-targeted chemotherapies. Safer and more effective therapeutic approaches than those currently in use are needed. Natural pomegranate peel extract (PPE) has recently been found to inhibit breast cancer progression; however, its mechanisms of action remain unclear. We hypothesized that transcriptional chan...
متن کاملGene-gene cooperativity in small networks.
We show how to construct a reduced description of interacting genes in noisy, small regulatory networks using coupled binary spin variables. Treating both the protein number and gene expression state variables stochastically and on equal footing, we propose a mapping that connects the molecular level description of networks to the binary representation. We construct a phase diagram indicating w...
متن کاملHigh Expression of Sphingosine Kinase 1 in Estrogen and Progesterone Receptors-Negative Breast Cancer
Background & objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. SPHK1 i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bulletin of Mathematical Biology
سال: 2018
ISSN: 0092-8240,1522-9602
DOI: 10.1007/s11538-018-0438-y